Choose the word or set of words that, when inserted in the sentence, best fits the meaning of the sentence as a whole. 

Bromelain, an enzyme found in pineapples, is not ------- in preventing bone and joint diseases, which can make bones susceptible to injury, but it can help injured bones -------.

1.   corrective . . heal
2.   effective . . recover
3.   detrimental . . multiply
4.   supportive . . degenerate
5.   vital . . persist